PLASMID-TEMPLATED SHAPE CONTROL OF CONDENSED DNA-BLOCK COPOLYMER NANOPARTICLES

 

"Plasmid-Templated Shape Control of Condensed DNA–Block Copolymer Nanoparticles". X. Jiang, W. Qu, D. Pan, Y. Ren, J. -M. Williford, H. Cui, E. Luijten, H. -Q. Mao. ADVANCED MATERIALS. In press. DOI: 10.1002/adma.201202932

DNA-containing micellar nanoparticles with distinctly different and highly uniform morphologies are prepared via condensation of plasmid DNA with a block copolymer of polyethylene glycol and a polycation in solvents of different polarity. Molecular dynamics simulations explain the underlying mechanism.

Se prepararon nanopartículas micelares que contienen ADN, con distintas morfologías altamente uniformes, mediante la condensación de plásmidos ADN con copolímeros de bloque de polietilenglicol y con un policatión en disolventes de diferente polarity. Simulaciones de dinámica molecular explican los mecanismos que los gobiernan.

http://onlinelibrary.wiley.com/doi/10.1002/adma.201202932/abstract