DNA SELF-ASSEMBLY OF TARGETED NEAR-INFRARED-RESPONSIVE GOLD NANOPARTICLES FOR CANCER THERMO-CHEMOTHERAPY

"DNA Self-Assembly of Targeted Near-Infrared-Responsive Gold Nanoparticles for Cancer Thermo-Chemotherapy". Z. Xiao, C. Ji, J. Shi, E. M. Pridgen, J. Frieder, J. Wu, O. C. Farokhzad. ANGEWANDTE CHEMIE INTERNATIONAL EDITION. In press. DOI: 10.1002/anie.201204018

Targeted cancer therapy: Inspired by the ability of DNA hybridization, a targeted near-infrared (NIR) light-responsive delivery system has been developed through simple DNA self-assembly (see picture; PEG=polyethylene glycol). This DNA-based platform shows the ability of releasing therapeutics upon near-infrared irradiation, and remarkable targeted thermo- and chemotherapeutic efficacy in vitro and in vivo.

Terapia dirigida contra el cancer: Inspirados por la capacidad de la hibridización del ADN, se ha desarrollado un sistema de liberación de medicamentos que responde ante iluminación con luz infrarroja cercana (NIR), a través del autoensamblaje sencillo del ADN (ver figura; PEG=polietilenglicol). Esta plataforma basada en ADN muestra la capacidad de liberar medicamento ante la iluminación con luz en el infrarrojo cercano, y muestra una destacada eficacia en termo y quimioterapias in vitro e in vivo.

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