"Multifunctionalized mesoporous silica nanoparticles for the in vitro treatment of retinoblastoma: Drug delivery, one and two-photon photodynamic therapy". M. Gary-Bobo, Y. Mir, C. Rouxel, D. Brevet, O. Hocine, M. Maynadier, A. Gallud, A. Da Silva, O. Mongin, M. Blanchard-Desce, S. Richeter, B. Loock, P. Maillard, A. Morère, M. Garcia, L. Raehm, J. -O. Durand. INTERNATIONAL JOURNAL OF PHARMACEUTICS. In press. DOI: 10.1016/j.ijpharm.2012.04.056
In this work, we focused on mesoporous silica nanoparticles (MSN) for
one photon excitated photodynamic therapy (OPE-PDT) combined with drug
delivery and carbohydrate targeting applied on retinoblastoma, a rare
disease of childhood. We demonstrate that bitherapy (camptothecin
delivery and photodynamic therapy) performed with MSN on retinoblastoma
cancer cells was efficient in inducing cancer cell death. Alternatively
MSN designed for two-photon excited photodynamic therapy (TPE-PDT) were
also studied and irradiation at low fluence efficiently killed
retinoblastoma cancer cells.
Este trabajo se centra en nanopartículas mesoporosas de dióxido de silicio (MSN) destinadas a la terapia fotodinámica mediante su excitación con un fotón (OPE-PDT), en combinación con la liberación de medicamentos y el etiquetamiento con carbohidratos aplicados al retinoblastoma, que es una rara enfermedad infantil. Se demuestra que la terapia doble (liberación de camptotecina y terapia fotodinámica) realizada con MSN sobre las células cancerosas de retinoblastoma fue una manera eficiente de eliminar a las células cancerosas. De forma alternativa, las MSN diseñadas para una terapia fotodinámica mediante su excitación con dos fotones (TPE-PDT) fueron estudiadas y con una irradiación de baja intensidad se pudieron eliminar células cancerosas de retinoblastoma.
This is very surprising information for me that silicon nanopartcles are used in VITRO. Till the date I knew that is used in electronic devices.
ReplyDeleteSilica (SiO2) nanoparticles are very versatile materials, but the silicon (Si) properties at the nanoscale are very interesting too. Even if both silicon and silica nanoparticles contain silicon (Si), their properties are quite different: the silicon is a semiconductor, the silica is a dielectric.
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